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  • Title: Probing bacterial-toxin inhibition with synthetic glycopolymers prepared by tandem post-polymerization modification: role of linker length and carbohydrate density.
    Author: Richards SJ, Jones MW, Hunaban M, Haddleton DM, Gibson MI.
    Journal: Angew Chem Int Ed Engl; 2012 Jul 27; 51(31):7812-6. PubMed ID: 22715146.
    Abstract:
    Probing the depths: A tandem post-polymerization modification strategy was used to systematically probe the multivalent inhibition of a bacterial toxin as a function of linker length (see scheme), carbohydrate density, and glycopolymer chain length. Guided by structural-biology information, the binding-pocket depth of the toxin was probed and used as a means to specifically improve inhibition of the toxin by the glycopolymer.
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