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  • Title: [Effect of chemical hepatic carcinogens and noradrenaline on the nucleoside phosphokinase activity of liver cells].
    Author: Gurkalo VK, Tret'iakov AV.
    Journal: Vopr Med Khim; 1979; 25(5):540-3. PubMed ID: 227170.
    Abstract:
    Distinct increase in activity of uridine kinase and pronounced decrease in thymidine kinase activity were observed in cell-free extracts of rat liver tissue at early stages of hepatocarcinogenesis caused by administration of N-nitrose diethylamine and 2-acetyl aminofluorene. Exogenous noradrepaline did not affect the altered activity of thymidine kinase but stimulated the effect of N-nitrose diethylamine and lowered the effect of 2-acetyl aminofluorene on the urindine kinase activity. Adrenergic neurotransmitters appear to influence the cell proliferation due to modification of the enzymes participating in the synthesis of nucleic acid precursors.
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