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  • Title: [Effect of carbostimulin and its mixture with vitamin D3 on the mineralization process of the bone callus in rabbits].
    Author: Taran TT, Gulyĭ MF, Brusko AT, Fanak NM, Dvornikova PD.
    Journal: Vopr Med Khim; 1979; 25(5):554-60. PubMed ID: 227171.
    Abstract:
    Mineralization of rabbit bone callus was studied within 15 days after resection of the upper part of radius bone inder conditions of treatment with carbostimuline and its mixture with vitamin D3. Content of calcium in the bone regenerate was increased by 40.8% after administration of carbostimuline and--by 70.5% after treatment with mixture containing vitamin D3. These preparations caused only slight effects on the phosphorus content. Dry residue in the regenerate os f animals, treated with the preparations, was increased approximately 2-fold (43% and 23%, respectively, p less than or equal to 0.001) as compared with control group. Content of citric acid was distinctly higher in the bone tissue of the treated animals. Within 15 days after the operation content of sialic acids wanormalized in blood serum of the animals. The data obtained were corroborated by X-ray and histologic examinations.
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