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  • Title: Migraine, serum serotonin and platelet 5-HT2 receptors.
    Author: Ribeiro CA, Cotrim MD, Morgadinho MT, Ramos MI, Santos ES, de Macedo Tdos R.
    Journal: Cephalalgia; 1990 Oct; 10(5):213-9. PubMed ID: 2272090.
    Abstract:
    In spite of recent theories about the aetiopathogenesis of migraine, serotonin continues to play a central role, explaining the efficacy of almost all migraine prophylactic drugs. In migraineurs with and without aura we measured (by HPLC-EC) the serum serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) levels between as well as during headache attacks. Between attacks of migraine with aura and at the beginning of attacks of both types of migraine the serum 5-HT and 5-HIAA concentration was significantly increased. These results were corroborated by 3H-spiperone binding to platelet membranes: in migraineurs with aura in the attack-free interval, there was a significant decrease in its Bmax, which suggests down-regulation of 5-HT2 receptors. In conclusion, we have verified that migraine with aura differs biochemically from migraine without aura.
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