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  • Title: Separase-dependent cleavage of pericentrin B is necessary and sufficient for centriole disengagement during mitosis.
    Author: Lee K, Rhee K.
    Journal: Cell Cycle; 2012 Jul 01; 11(13):2476-85. PubMed ID: 22722493.
    Abstract:
    Centriole disengagement is considered an essential step for licensing a new round of centriole duplication in the next cell cycle. Separase is critical for centriole disengagement. Here, we showed that pericentrin B (PCNTB) is specifically cleaved by separase at the exit of mitosis. The cleavage-resistant PCNTB mutant blocks the centriole disengagement and duplication. We also observed that an artificial cleavage of PCNTB during M phase induced premature disengagement of centrioles. Based on these results, we concluded that the separase-dependent cleavage of PCNTB is necessary and sufficient for centriole disengagement during mitosis.
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