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  • Title: [Long-term regional (catheter) infusion of anticoagulants and thrombolytics in the treatment of acute and chronic arterial occlusions in patients with thromboangiitis obliterans with severe ischemia of the limbs].
    Author: Bykov VM, Fust VI, Kolobova OI, Birman EA, Khorev NG.
    Journal: Gematol Transfuziol; 1990 Sep; 35(9):3-6. PubMed ID: 2272451.
    Abstract:
    Catheter heparin therapy combined with the intraarterial infusion of microcrystalline suspensions of antiinflammatory and immunosuppressive agents did not provide elimination of the microcirculation block in the affected limbs of the patients with severe ischemia of the limbs. Thrombolytics used in acute and chronic thromboses in most of cases did not help in complete recanalization of the arteries. Regional thrombolysis conducted before the basic course of the arterial infusion (heparin + immunosuppressants) in patients with distal forms of the arterial affections, promoted a significant improvement of conditions of the regional microcirculation. Application of this method has permitted lowering the rate of limb amputations.
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