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  • Title: Relaxin-like peptide in ascidians. I. Identification of the peptide and its mRNA in ovary of Herdmania momus.
    Author: Georges D, Tashima L, Yamamoto S, Bryant-Greenwood GD.
    Journal: Gen Comp Endocrinol; 1990 Sep; 79(3):423-8. PubMed ID: 2272463.
    Abstract:
    The ovaries of the ascidian Herdmania momus were extracted for relaxin. Relaxin immunoactivity was eluted from Sephadex G-50 in the position of authentic porcine ovarian relaxin and these fractions were parallel to porcine relaxin in an homologous porcine relaxin radioimmunoassay. Poly(A)+ RNA from ascidian ovaries hybridized to a 32P-labeled porcine relaxin B-chain 48 mer oligonucleotide probe. There was no hybridization with 32P-labeled probes of equal length but was rather directed to the B-chain of human relaxin or to two different regions of the C-peptide of porcine relaxin. We conclude that the ascidian ovary produces a relaxin-like molecule, possibly with greater homology in the B-chain to mammalian relaxins than in the C-peptide region.
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