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  • Title: Defective CSA-dependent granulopoiesis in patients with chronic drug-induced neutropenia.
    Author: Eliopoulos G, Meletis J, Fessas P, Anagnou NP.
    Journal: Haematologia (Budap); 1990; 23(2):101-9. PubMed ID: 2272534.
    Abstract:
    Colony stimulating activity (CSA) and granulocyte-macrophage progenitor cells (GM-CFC) were assayed in the bone marrow and peripheral blood of 17 patients with drug-induced chronic neutropenia. Leukocyte-derived and monocyte/macrophage-derived CSA from the neutropenic patients was found to be significantly decreased compared to normal control. However, bone marrow and peripheral blood GM-CFC were within normal limits. These data suggest that in neutropenic patients monocyte/macrophages exhibit most likely a qualitative defect in CSA production, which may account at least in part, for the impaired granulopoiesis observed in drug-induced neutropenia.
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