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  • Title: An alumina ceramic target vessel for the remote production of metallic radionuclides by in situ target dissolution.
    Author: Nagatsu K, Suzuki H, Fukada M, Minegishi K, Tsuji A, Fukumura T.
    Journal: Nucl Med Biol; 2012 Nov; 39(8):1281-5. PubMed ID: 22727820.
    Abstract:
    INTRODUCTION: As the use of metallic radionuclides increases, so does the demand for a simple production method. In this study, we demonstrated an in situ target processing concept for automated metallic radionuclide production without the use of any robotic device. METHODS: An alumina ceramic vessel for a vertical irradiation system was designed and developed. The ceramic vessel was evaluated by the production of Zr-89 using an yttrium powder target. The irradiated Y was dissolved remotely in HCl in the ceramic vessel and transferred as a solution to a hotcell through a Teflon tube. The crude Zr-89 was then purified by an automated apparatus. The Zr-89 was eluted with 100 μL of oxalic acid (solution) as the final product. RESULTS: The ceramic vessel gave a sufficient yield of Zr-89 (57±11MBq/μAh), showed good operability, and could be reused up to 10 times. With nominal irradiation (10μA×2h) in ~90 μL, the product (~940MBq) was obtained with >99.9% radionuclidic purity. CONCLUSION: The combination of the ceramic vessel and vertical irradiation has great potential for the remote production of various metallic radionuclides.
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