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  • Title: Prolonged and symptomatic bradycardia following a single dose of fingolimod.
    Author: Faber H, Fischer HJ, Weber F.
    Journal: Mult Scler; 2013 Jan; 19(1):126-8. PubMed ID: 22729989.
    Abstract:
    Fingolimod-related bradycardia is usually asymptomatic, reaches its nadir within 6 hours post-dose and recovers spontaneously. Here we report the case of a 30-year-old MS patient with vagotonia who developed symptomatic bradycardia with 33 beats per minute at nadir 39 hours after a single dose of fingolimod. Bradycardia was responsive to atropine, but returned within 2 hours. Overall, it took a week until the patient recovered. Extended monitoring is advised in patients with symptomatic bradycardia.
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