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  • Title: Investigation of the hyper-reflective inner/outer segment band in optical coherence tomography of living frog retina.
    Author: Lu RW, Curcio CA, Zhang Y, Zhang QX, Pittler SJ, Deretic D, Yao XC.
    Journal: J Biomed Opt; 2012 Jun; 17(6):060504. PubMed ID: 22734727.
    Abstract:
    This study is to test anatomic correlates, including connecting cilium (CC) and inner segment (IS) ellipsoid, to the hyper-reflective band visualized by optical coherence tomography (OCT) and commonly attributed to the photoreceptor inner/outer segment (IS/OS) junction. A line-scan OCT (LS-OCT) was constructed to achieve sub-cellular resolution (lateral: ≈ 2 μm; axial: ≈ 4 μm) of excised living frog retinas. An electro-optic phase modulator was employed for rapid and vibration-free phase modulation. Comparison of normalized distance measurements between LS-OCT images and histological images revealed that the dominant source of the signal reported as the IS/OS OCT band actually originates from the IS.
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