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  • Title: Cerebral venous sinus thrombosis secondary to typhoid fever: a case report and brief summary of the literature.
    Author: Pineda MC, Lopinto-Khoury C.
    Journal: Neurologist; 2012 Jul; 18(4):202-3. PubMed ID: 22735245.
    Abstract:
    BACKGROUND: There have been few reports of typhoid fever (or salmonellosis) presenting with cerebral venous sinus thrombosis. We present such a case to highlight the importance of recognizing an etiology for cerebral sinus thrombosis and to discuss the role of salmonella in thrombogenesis. PATIENT: A 19-year-old man with a history of migraine presented with headache, nausea, vomiting, and fever, and was found to have a cerebral venous sinus thrombosis on magnetic resonance venography. He later developed profuse watery diarrhea and cultures grew salmonella species, consistent with typhoid fever. RESULTS: Treatment with antibiotics and oral anticoagulation led to resolution of his symptoms within 2 days and recanalization of the thrombosis was proven on magnetic resonance venography 6 months later. CONCLUSIONS: The development of profuse diarrhea after thrombosis suggests a direct thrombogenic effect of salmonella independent of dehydration. Systemic infections should be considered in all patients with thrombosis to identify treatable causes.
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