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  • Title: Transoral laser microsurgery of recurrent early glottic cancer after radiation therapy: clinical feasibility and limitations.
    Author: Han YJ, Lee HS, Kim SW, Hong JC, Kim ST, Park HS, Lee KD.
    Journal: Ann Otol Rhinol Laryngol; 2012 Jun; 121(6):375-82. PubMed ID: 22737959.
    Abstract:
    OBJECTIVES: Transoral laser microsurgery (TLM) is an accepted alternative to open partial laryngectomy for selected glottic cancers, but its role in salvage of radiation failure is debated. METHODS: The records of 18 patients treated by TLM for rT1 and rT2 glottic cancer after curative radiation therapy from 2002 to 2007 were retrospectively analyzed. RESULTS: Of the 18 patients, 10 (56%) remained free of disease after the first TLM. The 5-year local control and laryngeal preservation rates showed better outcomes in rpT1 tumors than in rpT2 tumors (87.5% versus 16.6%, p = 0.02; and 87.5% versus 33.3%, p = 0.03, respectively). However, the 5-year overall survival and disease-specific survival rates showed no significant difference between rpT1 and rpT2 tumors. CONCLUSIONS: TLM can be a relatively safe and effective salvage option for rT1 glottic cancer. However, because of its high local recurrence rate, TLM may not be generally recommended for rT2 glottic cancer.
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