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  • Title: [Role of alkaline phosphatase Regan isoenzyme in prognosis of patients with osteosarcoma].
    Author: Tucci A, Saviano C, Del Prete S.
    Journal: Medicina (Firenze); 1990; 10(2):158-60. PubMed ID: 2273951.
    Abstract:
    The presence of Regan isoenzyme (the heat stable fraction of alkaline phosphatase) in serum of patients with osteosarcoma has been proposed as a prognostic factor indicating the metastatic evolution of the disease. This work reports on 9 patients with osteosarcoma. In 4 of them Regan isoenzyme was present 4, 6, 12, and 16 months before clinical-instrumental evidence of lung metastases. These results further support the significance of this isoenzyme as a marker of relapse in an early subclinical stage.
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