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  • Title: A novel molecularly imprinted electrochemiluminescence sensor for isoniazid detection.
    Author: Wu B, Wang Z, Xue Z, Zhou X, Du J, Liu X, Lu X.
    Journal: Analyst; 2012 Aug 21; 137(16):3644-52. PubMed ID: 22741161.
    Abstract:
    Based on Ru(bpy)(3)(2+)-Au nanoparticles decorated multi-walled carbon nanotubes composites and a molecularly imprinted polymer (MIP), we propose a novel molecularly imprinted electrochemiluminescence (ECL) sensor to selectively determine isoniazid (INH). The MIP is synthesized through electrochemical copolymerization of acrylamide and N,N'-methylene diacrylamide in the presence of INH template molecules. The enhanced ECL intensity is linear in the range of 0.1 to 110 μg cm(-3) and the detection limit is 0.08 μg cm(-3) (3σ) INH with relative standard deviation 3.8% (n = 6) for 8 μg cm(-3). As a result, the sensor has been successfully applied to the determination of INH in human urine and pharmaceutical samples. Moreover, the possible ECL mechanism is discussed.
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