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Title: Selective inhibition of inducible nitric oxide synthase by derivatives of acetamidine. Author: Maccallini C, Patruno A, Ammazzalorso A, De Filippis B, Fantacuzzi M, Franceschelli S, Giampietro L, Masella S, Tricca ML, Amoroso R. Journal: Med Chem; 2012 Nov; 8(6):991-5. PubMed ID: 22741778. Abstract: A new series of phenyl- and heteryl acetamidines were synthesized and evaluated as inhibitors of nitric oxide synthases (NOS). While the N-substitution of the acetamidine moiety with different heterocycles appears to completely destroy the activity, linking the phenyl core preserves it. Moreover, it was observed a strong dependence of the phenylacetamidines potency of action from the length of the alkyl chain that connects the aromatic ring to the acetamidine moiety.[Abstract] [Full Text] [Related] [New Search]