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  • Title: [Immunoscintigraphy of malignant melanoma].
    Author: Nicol L, Sandron A, Herry JY, Chevrant-Breton J.
    Journal: Pathol Biol (Paris); 1990 Oct; 38(8):866-9. PubMed ID: 2274393.
    Abstract:
    This work is part of a multicentric European evaluation of the monoclonal antibody 225.28s targeted against malignant melanoma and its metastases. Twenty-eight patients (12 males, 16 females, mean age: 53 yrs), who had initially been treated by resection of the primary tumour, were included in the study. Twenty-three of the 26 metastases more than 1 cm in diameter were visualized by immunoscintigraphy. The sensitivity of the procedure (88%) is limited however by the small size of the lesions and their depth, as well as by background noise caused by circulating antibodies. Immunoscintigraphy enables non-invasive investigation of the whole body and can detect lesions that other conventional complementary explorations fail to identify.
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