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  • Title: Increased number of beta-adrenergic receptors in the hypertrophied myocardium.
    Author: Limas CJ.
    Journal: Biochim Biophys Acta; 1979 Nov 15; 588(1):174-8. PubMed ID: 227473.
    Abstract:
    Development of cardiac hypertrophy is associated with depletion of endogenous catecholamine stores and increased inotropic response to exogenous catecholamines. A biochemical basis for these changes is provided by the observation that the number of cardiac beta-adrenergic receptors - as reflected in specific [3H]dihydroalprenolol binding - is increased in hypertrophy without a change in the affinity of dihydroalprenolol for the binding sites or in the capacity of isoproterenol to displace dihydroalprenolol. This change in beta-receptor numbers may be an important adaptive mechanism for preserving the contractile performance of the hypertrophied myocardium.
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