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  • Title: Synthesis and antitumor activity of novel quinazoline derivatives containing thiosemicarbazide moiety.
    Author: He J, Wang X, Zhao X, Liang Y, He H, Fu L.
    Journal: Eur J Med Chem; 2012 Aug; 54():925-30. PubMed ID: 22749192.
    Abstract:
    Series of novel derivatives of quinazoline containing thiosemicarbazide moiety 5 and 9 have been synthesized and tested for their antitumor activities in vitro against a panel of five human cancer cell lines. Bioassay results indicated that most of the prepared compounds exhibited cytotoxicity against various cancer cells. From the structure-activity relationships it was found that unsubstituted quinazoline ring and benzene ring or halogen substituted benzene ring in quinazoline derivatives 5 and 9 would be the most favorable for their antitumor activity.
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