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  • Title: Life-threatening disseminated tuberculosis as a complication of treatment by infliximab for Crohn's disease: report of two cases, including cerebral tuberculomas and miliary tuberculosis.
    Author: Tissot C, Couraud S, Meng L, Girard P, Avrillon V, Gérinière L, Perrot E, Souquet PJ.
    Journal: J Crohns Colitis; 2012 Oct; 6(9):946-9. PubMed ID: 22749231.
    Abstract:
    Tumor necrosis factor α antagonist therapies represent an increased risk of reactivation of tuberculosis. We report two cases of life-threatening disseminated tuberculosis in patients undergoing treatment with infliximab for Crohn's disease including one case of a patient with cerebral tuberculomas. We discuss the implication of tumor necrosis factor α in the genesis of tuberculosis infection and the features of tuberculosis under infliximab. Tuberculosis screening and eventually preventive chemotherapy should become the standard of care for individual undergoing tumor necrosis factor α antagonist therapies.
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