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  • Title: Guanacastane-type diterpenoids with cytotoxic activity from Coprinus plicatilis.
    Author: Liu Y, Li Y, Ou Y, Xiao S, Lu C, Zheng Z, Shen Y.
    Journal: Bioorg Med Chem Lett; 2012 Aug 01; 22(15):5059-62. PubMed ID: 22749279.
    Abstract:
    Four new guanacastane-type diterpenoids (1-4), together with the known compound, guanacastepene E (5), were isolated from a basidiomycete of the macro-fungi, Coprinus plicatilis 82. Their structures were elucidated on the basis of extensive spectroscopic analyses, including FT-ICR-MS, UV, IR and 1D and 2D NMR experiments. The in vitro cytotoxic activities of all compounds against the human cancer cell lines HepG2, HeLa, MDA-MB-231, BGC-823, HCT 116, and U2OS were evaluated, only compound 1 exhibited significant cytotoxicities with IC(50) values ranging from 1.2 to 6.0 μM.
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