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  • Title: Synthesis and biological evaluation of novel (E) stilbene-based antitumor agents.
    Author: Csuk R, Albert S, Siewert B, Schwarz S.
    Journal: Eur J Med Chem; 2012 Aug; 54():669-78. PubMed ID: 22749392.
    Abstract:
    Several new (E) stilbenes were synthesized by a combination of a Wittig olefination followed by Mizoroki-Heck coupling reactions. These compounds were screened for antitumor activity in a panel of 8 human cancer cell lines by a colorimetric SRB assay. Several of these compounds exhibit strong cytotoxicity. The most active compound of this series showed an average IC(50) value of 0.03 μmol; it acts by apoptosis as shown by a dye-exclusion test, an extra acridine orange/ethidium bromide staining and DNA-laddering experiments.
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