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  • Title: [Indices of the functional state of the hypothalamus-hypophysis-ovaries system in women with Itsenko-Cushing disease].
    Author: Manusharova RA.
    Journal: Vrach Delo; 1990 Apr; (4):74-7. PubMed ID: 2275178.
    Abstract:
    The content of gonadotropic hormones, prolactin and sex steroids were examined in the blood of 97 women with Itsenko-Cushing disease before and after administration of LH-RH and chorionic gonadotropin hormone. It was found that women with Itsenko-Cushing disease revealed a reduced concentration of gonadotropic hormones while the level of testosterone, progesterone, prolactin was increased. Estradiol remained unchanged. LH-RH tests indicate that women with Itsenko-Cushing disease revealed an abnormal synthesis and release of gonadotropins as well as secretion of LH-RH by the hypothalamus. The chorionic gonadotropin hormone test confirmed maintenance of the ovarian function.
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