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  • Title: Successful treatment with tocilizumab in a case of Cogan's syndrome complicated with aortitis.
    Author: Shibuya M, Fujio K, Morita K, Harada H, Kanda H, Yamamoto K.
    Journal: Mod Rheumatol; 2013 May; 23(3):577-81. PubMed ID: 22752533.
    Abstract:
    A 69-year-old man with sensorineural hearing loss and iritis was diagnosed with atypical Cogan's syndrome. He had several systematic manifestations: aortitis, meningitis, panniculitis and seronegative arthritis. Remission induced by treatment with high doses of prednisolone was followed by relapse within 1 year. Although his condition was resistant to various immunosuppressive drugs, including methotrexate, cyclosporine, azathioprine and adalimumab, his symptoms, inflammatory response and quality of life measures were successfully improved by tocilizumab, a humanized anti-interleukin-6 receptor antibody.
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