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  • Title: Cycloartane-type triterpene glycosides from the rhizomes of Cimicifuga heracleifolia and their anticomplementary activity.
    Author: Lee JH, Cuong TD, Kwack SJ, Seok JH, Lee JK, Jeong JY, Woo MH, Choi JS, Lee HK, Min BS.
    Journal: Planta Med; 2012 Aug; 78(12):1391-4. PubMed ID: 22753039.
    Abstract:
    Seven known triterpene glycosides, 23-O-acetylshengmanol 3-O-α-L-arabinopyranoside (1), 23-O-acetylshengmanol 3-O-β-D-xylopyranoside (2), 24-epi-24-O-acetylhydroshengmanol 3-O-β-D-xylopyranoside (3), cimiaceroside B (4), (23R,24S)-cimigenol 3-O-β-D-xylopyranoside (5), (23R,24R)-25-O-acetylcimigenol 3-O-β-D-xylopyranoside (6) and (23R,24S)-25-O-anhydrocimigenol 3-O-β-D-xylopyranoside (7) were isolated from the rhizomes of Cimicifuga heracleifolia. Their chemical structures were determined on the basis of spectroscopic analyses including 2D NMR. All isolates were investigated for their inhibitory effects on the classical pathway of the complement system. Among them, compound 6 showed strong inhibitory activity with an IC₅₀ value of 7.7 µM while compound 3 was moderately active with an IC₅₀ value of 195.6 µM.
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