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  • Title: [Effects of neferine on heart electromechanical activity in anaesthetized cats].
    Author: Li GR, Qian JQ, Lü FH.
    Journal: Zhongguo Yao Li Xue Bao; 1990 Mar; 11(2):158-61. PubMed ID: 2275392.
    Abstract:
    Neferine, an alkaloid extracted from the green seed embryo of Nelumbo nucifera Gaertn, has been shown to have anti-arrhythmic action. Neferine 1-10 mg/kg iv dose-dependently decreased the monophasic action potential amplitude (MAPA), prolonged the monophasic action potential duration (MAPD). It also decreased LVP, dP/dt, prolonged SCL, and reduced arterial blood pressure in a dose-dependent manner. These effects were similar to those of quinidine, and different from tetrandrine. The latter had an inhibitory effect on LVP and dP/dt, but had no influence on MAPA and MAPD. The results indicate that neferine and quinidine have similar effects on heart electro-mechanical activity.
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