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  • Title: Understanding the significance of low-level preformed donor-specific anti-HLA antibodies in renal transplant patients.
    Author: Wu P, Everly MJ, Jin J, Mao Y, Chen J.
    Journal: Clin Transpl; 2011; ():365-8. PubMed ID: 22755432.
    Abstract:
    This is a single center, retrospective cohort study showing the impact of pre-transplant HLA-DSA (detected by the SAFB) on early posttransplant rejection rates. Our results showed that low level pretransplant DSA detected by SAFB is associated with a high risk of early clinical AMR. However, not all patients with pretransplant DSA will go on to develop AMR. Post-transplant with a decrease/removal of DSA within one month will lead to a low rate of AMR. Conversely, those who have a high DSA MFI are at the highest risk of early AMR. These findings support using SAFB for pretransplant assessment and early posttransplant monitoring.
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