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  • Title: Synthesis and kinetic characterisation of omega-guanidinocarbonic acid ethyl esters as trypsin substrates.
    Author: Schuster M, Medvedkin VN, Schellenberger V, Mitin YuV, Jakubke HD.
    Journal: Biomed Biochim Acta; 1990; 49(6):519-21. PubMed ID: 2275728.
    Abstract:
    Aliphatic omega-guanidinocarbonic acid ethyl esters of different chain length (C3-C6) were synthesized and characterized as 4-toluenesulfonates. The kinetic parameters of the trypsin-catalyzed hydrolysis indicate that the ethyl ester of delta-guanidinovaleric acid is the most effective substrate in this series. The Km value of this compound is in the same order of magnitude as those of arginine-containing ester substrates like N alpha-benzoylarginine ethyl ester (BAEE). However, kcat is decreased by approximately two orders of magnitude.
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