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  • Title: [Increased INR from concomitant use of acenocoumarol and capecitabine].
    Author: Tomlow B, Voll ML, Smorenburg CH.
    Journal: Ned Tijdschr Geneeskd; 2012; 156(26):A4793. PubMed ID: 22759711.
    Abstract:
    BACKGROUND: A drug interaction between capecitabine and coumarin may result in an increased INR and bleeding complications. CASE DESCRIPTION: We describe an 80-year-old woman who presented with rectal bleeding and an increased INR due to the concomitant use of acenocoumarol and capecitabine for atrial fibrillation and metastatic cecal cancer, respectively. CONCLUSION: In patients with a compelling indication for treatment with capecitabine and anticoagulant therapy, conversion to low-molecular weight heparin should be considered.
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