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  • Title: Central nervous system aquaporin-4 autoimmunity presenting with an isolated cerebral abnormality.
    Author: Kim SH, Kim W, Kook MC, Hong EK, Kim HJ.
    Journal: Mult Scler; 2012 Sep; 18(9):1340-3. PubMed ID: 22760103.
    Abstract:
    Advances in the understanding of central nervous system aquarporin-4 autoimmunity have promoted the recognition of diverse clinical presentations beyond the traditional view of neuromyelitis optica. We describe a patient who developed hemiparesis caused by an extensive cerebral lesion as an initial manifestation of central nervous system aquarporin-4 autoimmunity. Although the patient had no history of optic neuritis or myelitis, not only was serum anti-aquarporin-4 antibody positive, but an imaging, treatment response and histopathological features also revealed characteristic findings suggestive of central nervous system aquarporin-4 autoimmunity. The present case highlights the importance of a comprehensive evaluation for anti-aquarporin-4 antibody even in patients presenting with isolated cerebral lesions.
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