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  • Title: Intravenous fluorescein as a cause of immunoglobulin E-mediated anaphylactic shock.
    Author: Breidablik A, De Pater GH, Walther C, Nopp A, Guttormsen AB.
    Journal: Acta Anaesthesiol Scand; 2012 Sep; 56(8):1066-8. PubMed ID: 22762373.
    Abstract:
    We report a patient with severe anaphylactic shock immediately after injection of i.v. fluorescein. The patient recovered without sequela. Immunoglobulin E (IgE) mechanism was highly suggestive with significant increase in serum tryptase, positive basophil allergen threshold sensitivity (CD-sens) and histamine release tests towards fluorescein. This is, to our knowledge, the first report where CD-sens has been used to aid in diagnosing an IgE-mediated anaphylactic shock caused by fluorescein.
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