These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Effects of electroacupuncture on T-lymphocytes, spleen index, thymus index and lymphopoiesis levels in strenuous exercise-induced stress rats].
    Author: Lu YM, Zhang H.
    Journal: Zhen Ci Yan Jiu; 2012 Apr; 37(2):136-9. PubMed ID: 22764600.
    Abstract:
    OBJECTIVE: To observe the effect of electroacupuncture (EA) on levels of T-lymphocytes, spleen index, thymus index and lymphopoiesis in strenuous exercise-induced immunosuppression rats, so as to study its mechanisms underlying improving immune function of strenuous training athletes. METHODS: A total of 43 SD rats were randomly allocated to control (n = 10), model (n = 17) and EA (n = 16) groups. Immunosuppression model was established by forcing the rat to swim for 150 min in a water tank, once daily, 6 times a week and for 8 weeks. EA (2 Hz, < 1 mA) was applied to bilateral "Zusanli" (ST 36), "Baihui" (GV 20) and "Guanyuan" (CV 4) for 20 min, once daily for 7 weeks. Spleen weight and thymus weight were detected after killing the anesthetized rats for calculating spleen index and thymus index, separately. Peripheral blood T cell subsets were measured by using flow cytometer, and lymphopoiesis was detected by using 3H-thymidine deoxyribonucleotide (3H-TdR) incorporation. RESULTS: In comparison with the control group, spleen index, thymus index, lymphopoiesis and CD3+ levels of the model group were decreased significantly (P < 0.01, P < 0.05). Compared with the model group, peripheral blood CD3+, CD4+ and NKC levels, and thymus and spleen indexes were increased considerably in EA group (P < 0.01, P < 0.05). No significant differences were found between the control and model groups in CD4+, CD8+ and CD4+ /CD8+ and NKC levels, and between the model and EA groups in CD8+ and CD4+/CD8+ levels (P > 0.05). CONCLUSION: EA intervention can effectively upregulate peripheral blood CD3+, CD4+ and NKC, and thymus and spleen indexes in strenuous training rats, which may contribute to its effect in relieving strenuous exercise-induced immunosuppression.
    [Abstract] [Full Text] [Related] [New Search]