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  • Title: Which is the best technique for endometrial sampling? Aspiration (pipelle) versus dilatation and curettage (D&C).
    Author: Demirkiran F, Yavuz E, Erenel H, Bese T, Arvas M, Sanioglu C.
    Journal: Arch Gynecol Obstet; 2012 Nov; 286(5):1277-82. PubMed ID: 22766754.
    Abstract:
    PURPOSE: To compare diagnostic accuracy and adequacy of pipelle endometrial biopsy with dilatation and curettage. METHODS: From October 2007 to November 2009, 673 patients were evaluated with pipelle endometrium biopsy, D&C and hysterectomy in the Department of Obstetrics and Gynecology, Istanbul University Cerrahpasa Medical Faculty. 478 patients underwent pipelle and D&C, 212 patients underwent pipelle and hysterectomy and 161 patients underwent D&C and hysterectomy. Uterine findings were grouped under five headings: normal, hyperplasia, focal lesion, atypia, and atrophy. Histologic sections from pipelle biopsy or D&C specimens were compared with each other and hysterectomy specimens. Chi-square, Mc.Nemar, and Fisher-exact tests were used as appropriate. The sensitivity, specificity, positive predictive value, and negative predictive value were calculated for each method used in the study. RESULTS: We compared the histological results of pipelle biopsy and D&C. Statistically outcomes of pipelle and D&C were concordant with each other. Concordance rate was 67 % between pipelle and hysterectomy and 70 % between D&C and hysterectomy. Sensitivity of pipelle biopsy in detection of hyperplasia and aytpia was 67 and 75 %, respectively. Sensitivity of D&C for detecting hyperplasia and atypia was 62 and 83 %. NPV of pipelle biopsy and D&C was 99 % for malignancy. CONCLUSIONS: Pipelle biopsy and D&C showed almost equal success rate in the diagnosis of endometrial pathologies. Neither pipelle nor D&C is adequate method for focal endometrial pathologies. Both biopsy methods are not perfect, but pipelle biopsy is a cheaper and easy technique compared with D&C, and ultrasonographic findings of endometrium should be considered prior to endometrial biopsy.
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