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  • Title: Additive manufacturing of wet-spun polymeric scaffolds for bone tissue engineering.
    Author: Puppi D, Mota C, Gazzarri M, Dinucci D, Gloria A, Myrzabekova M, Ambrosio L, Chiellini F.
    Journal: Biomed Microdevices; 2012 Dec; 14(6):1115-27. PubMed ID: 22767245.
    Abstract:
    An Additive Manufacturing technique for the fabrication of three-dimensional polymeric scaffolds, based on wet-spinning of poly(ε-caprolactone) (PCL) or PCL/hydroxyapatite (HA) solutions, was developed. The processing conditions to fabricate scaffolds with a layer-by-layer approach were optimized by studying their influence on fibres morphology and alignment. Two different scaffold architectures were designed and fabricated by tuning inter-fibre distance and fibres staggering. The developed scaffolds showed good reproducibility of the internal architecture characterized by highly porous, aligned fibres with an average diameter in the range 200-250 μm. Mechanical characterization showed that the architecture and HA loading influenced the scaffold compressive modulus and strength. Cell culture experiments employing MC3T3-E1 preosteoblast cell line showed good cell adhesion, proliferation, alkaline phosphatase activity and bone mineralization on the developed scaffolds.
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