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  • Title: Viral markers in patients with hemophagocytosis: a prospective study in a tertiary care hospital.
    Author: Mishra B, Varma N, Appannanavar S, Malhotra P, Sharma M, Bhatnagar A, Ratho RK, Varma S.
    Journal: Indian J Pathol Microbiol; 2012; 55(2):215-7. PubMed ID: 22771647.
    Abstract:
    BACKGROUND: Hemophagocytic syndrome (HPS) is a rare clinicopathological condition characterized by the activation of macrophages with prominent hemophagocytosis in bone marrow and other reticulo-endothelial systems. HPS can be familial or secondary to infections including viruses. AIM: To study the viral markers in patients with HPS. MATERIALS AND METHODS: Serum samples of patients with HPS and control group were screened for anti EBV VCA IgM, and IgG, anti-Parvo B19 IgM, and anti-CMV IgM antibodies using commercially available ELISA kits and CMV and ParvoB19 DNA by polymerase chain reaction (PCR). RESULTS AND DISCUSSION: The present prospective study reports the profile of viral markers in HPS cases from north India. Among the 14 HPS cases 43% (6/14) were positive for at least one viral marker tested, of which EBV was found to be the most prevalent (3/6: 50%) followed by parvovirus B19(2/6: 33%) and cytomegalovirus (1/6: 17%). Mortality was noted in 33% of virus associated HPS patients. Our study highlights the higher association of Epstein-Barr virus (EBV) with HPS as compared to other viruses along with higher rate of mortality in both parvovirus B 19 and EBV associated HPS.
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