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  • Title: Protein conformational studies for macromolecularly imprinted polymers.
    Author: Kryscio DR, Fleming MQ, Peppas NA.
    Journal: Macromol Biosci; 2012 Aug; 12(8):1137-44. PubMed ID: 22777744.
    Abstract:
    CD is used to clearly show the negative impact of common ligands on the overall conformation of BSA, a typical protein template in macromolecularly imprinted polymers. This change occurs at concentrations far lower than those generally used in the literature. These findings are important as they offer insight into a potential fundamental reason for the lack of success in protein imprinting to date despite significant interest from the scientific community.
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