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  • Title: Design, synthesis and antimicrobial properties of novel 3,3a,4,5,6,7- hexahydroindazole and arylthiazolylpyrazoline derivatives.
    Author: Bishnoi A, Singh S, Tiwari AK, Sethi A, Tripathi CM.
    Journal: Med Chem; 2013 Feb; 9(1):45-52. PubMed ID: 22779793.
    Abstract:
    A remarkable diastereoselective synthesis of some novel arylthiazolyl pyrazoline derivatives 3(a-l) is displayed which were evaluated for their in vitro antimicrobial activities. In particular, compounds 3e, 3g & 3l (MIC 12.5 μg /ml) showed good activity against S. aureus and compounds 3b & 3j (MIC 12.5 μg / ml) against B. subtilis. Compounds 3g, 3i, 3j (MIC 12.5 μg/ ml) and 3l (MIC 6.25 μg / ml) also displayed excellent antifungal activity against C. albicans. Of all the synthesized compounds, 3g and 3e exerted a wide range of antibacterial activities against entire tested gram positive (S. aureus and B. subtilis) and gram negative (E. coli and P. aeruginosa) bacterial strain except P. aeruginosa.
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