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  • Title: Inotropic activities of imidazopyridines.
    Author: Barraclough P, Black JW, Cambridge D, Gerskowitch VP, Hull RA, Lyer R, King WR, Kneen CO, Nobbs MS, Shah GP.
    Journal: Arch Pharm (Weinheim); 1990 Aug; 323(8):501-5. PubMed ID: 2278516.
    Abstract:
    A series of 2-substituted 1H-imidazo[4,5-b]pyridines and the isomeric 1H-imidazo[4,5-c]pyridine derivatives has been prepared and evaluated as inotropic agents. The 1H-imidazo-[4,5-b] derivatives were found to be consistently more potent than their isomers in the [4,5-c] series in isolated guinea pig papillary muscle preparations. Structure-activity relationships and the species-dependence of inotropic potencies are discussed.
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