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  • Title: [Usefulness of clobazam in the treatment of refractory epilepsy in children].
    Author: Dávila-Gutiérrez G, Mondragón-Pineda A, Alcalá-Negrete H.
    Journal: Bol Med Hosp Infant Mex; 1990 Oct; 47(10):694-7. PubMed ID: 2278646.
    Abstract:
    Below is report on our experience using a relatively new benzodiazepine as treatment for refractory epilepsy in 30 children. All of the patients had a severely fixed encephalopathy; 17 presented mixed epilepsy, 9 had Lennox-Gastaut syndrome and 4 others, West Syndrome. The seizures were totally controlled in 20% of the children; in a proportion superior to 75%, seizures were decreased in 46% of the patients. There were positive results in 6% of the cases and side-effects were seen in 13%. The usefulness of the clobazam as a co-adjuvant medication in the control of refractory epileptic seizures was demonstrated since the number of seizures decreased from 15 to 3 per day.
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