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  • Title: Label free fluorescence turn-on detection of polynucleotide kinase activity with a perylene probe.
    Author: Jiao H, Wang B, Chen J, Liao D, Li W, Yu C.
    Journal: Chem Commun (Camb); 2012 Aug 14; 48(63):7862-4. PubMed ID: 22786467.
    Abstract:
    A single stranded oligonucleotide could induce aggregation of a perylene probe, the probe's monomer fluorescence was efficiently quenched. However, when the oligonucleotide was 5'-phosphorylated by polynucleotide kinase, it could be very efficiently degraded by lambda exonuclease, probe monomers were released, and a turn on fluorescence signal was detected.
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