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  • Title: [Neuromyelitis optica in children. Two case reports].
    Author: Tosello B, Halbert C, Mancini J, Chabrol B, Boucraut J, Milh M.
    Journal: Arch Pediatr; 2012 Aug; 19(8):827-31. PubMed ID: 22789744.
    Abstract:
    Devic neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the central nervous system associating acute transverse myelitis and optic neuritis. This is a different disease from multiple sclerosis for which the presence of the NMO antibody directed against aquaporin 4 is a specific marker. Brain damage on MRI does not exclude the diagnosis; the location is superposable in the brain zones rich in aquaporin 4 channels. We report 2 cases of NMO with anti-aquaporin 4. One patient was not symptomatic of brain damage. In this patient, the affinity of anti-NMO for aquaporin 4, studied by flow cytometry, was particularly high. Both patients were treated with immunosuppressive agents (rituximab) due to the failure of or dependence on high-dose corticosteroids.
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