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  • Title: [Effects of undecapeptide hydra morphogen on processes of cell division in the corneal and tongue epithelium of white rats].
    Author: Khomichuk AIu, Timoshin SS.
    Journal: Biull Eksp Biol Med; 1990 Oct; 110(10):425-7. PubMed ID: 2279100.
    Abstract:
    We studied the effects of one and five time administration of peptide morphogen of hydra (PMH) in a dose of 10 micrograms/kg on cell division and DNA-synthesis in corneal and tongue epithelium of white rats. PMH stimulated cell proliferation considerably. This was revealed in acceleration of mitosis, and in rising of quantity of DNA-synthesis nuclei in 1.5-2.1 time after a single injection. In 24 hours after the five time administration the number of DNA-synthesis nuclei increased 1.5 and 1.9 time in corneal and tongue epithelium, correspondingly. This data reflects the possible role of PMH in structural homeostasis regulation.
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