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  • Title: Mechanisms involved in alpha-adrenergic effects of catecholamines on liver metabolism.
    Author: Exton JH.
    Journal: J Cyclic Nucleotide Res; 1979; 5(4):277-87. PubMed ID: 227945.
    Abstract:
    Recent results have indicated that alpha-adrenergic receptors are the major mediators of catecholamine actions on liver metabolism in several species. It is well-established that cAMP and cAMP-dependent protein kinase are not involved in hepatic alpha-adrenergic effects. This review presents evidence that alpha-adrenergic stimulation of glycogenolysis in rat liver involves the mobilization of Ca2+ ions from mitochondria and stimulation of phosphorylase kinase by the resulting increase in cytosolic Ca2+ concentration. Possible mechanisms by which activation of alpha-adrenergic receptors causes release of mitochondrial Ca2+ and affects other cell processes are discussed.
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