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  • Title: Enhancement of haemopoietic recovery in sublethally gamma-irradiated mice by the joint use of indomethacin and cystamine.
    Author: Kozubík A, Pospísil M, Netíková J.
    Journal: Folia Biol (Praha); 1990; 36(6):291-300. PubMed ID: 2279583.
    Abstract:
    The effects of indomethacin and cystamine, administered prior to gamma-irradiation of mice, were investigated. Synergistic enhancement of haemopoietic recovery was observed under the conditions of a joint use of both drugs. The reason for this synergistic action is probably a joint operation of two mechanisms, i.e., the lowering of the radiosensitivity of haemopoietic stem cells by cystamine and the increase of the proliferation of surviving haemopoietic cells by indomethacin.
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