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  • Title: Molecular characteristics of extended-spectrum β-lactamase-producing Escherichia coli in Japan: emergence of CTX-M-15-producing E. coli ST131.
    Author: Kuroda H, Yano H, Hirakata Y, Arai K, Endo S, Kanamori H, Yamamoto H, Ichimura S, Ogawa M, Shimojima M, Komatsu M, Jonai T, Itagaki S, Nonomiya Y, Suwabe A, Kaku M.
    Journal: Diagn Microbiol Infect Dis; 2012 Oct; 74(2):201-3. PubMed ID: 22796185.
    Abstract:
    We investigated the molecular characteristics of ESBL-producing Escherichia coli in Japan. A total of 101 clinical isolates of ESBL-positive E. coli collected in Japan between June 2008 and November 2009 were studied. Among the 101 strains, 97 were positive for CTX-M, while 47 and two were positive for TEM and SHV, respectively. Sequencing revealed that CTX-M-14 was most common (49/101), followed by CTX-M-27 (22/101) and CTX-M-15 (8/101). Based on MLST data, seven of eight CTX-M-15 producers belonged to ST131. This is the first report about clinical isolates of E. coli ST131 possessing CTX-M-15 in Japan.
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