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  • Title: Triptolide inhibits proliferation and induces apoptosis of human melanoma A375 cells.
    Author: Tao Y, Zhang ML, Ma PC, Sun JF, Zhou WQ, Cao YP, Li LJ.
    Journal: Asian Pac J Cancer Prev; 2012; 13(4):1611-5. PubMed ID: 22799376.
    Abstract:
    Triptolide, a diterpenoid obtained from Tripteryglum wilfordii Hook.f, has attracted interest for its anti- tumor activities against human tumor cell lines in recent years. This report focuses on anti-proliferative and pro-apoptotic activities in human melanoma A375 cells assessed by CCK8 assay, Hoechst 33258 staining and flow cytometry. In addition, triptolide-induced arrest in the S phase was also observed. Caspase assays showed the apoptosis induced by triptolide was caspase-dependent and probably through intrinsic apoptotic pathways. Furthermore, expression of NF-κB (p65) and its downstream factors such as Bcl-2, Bcl-XL was down-regulated. Taken together, the data indicate that triptolide inhibits A375 cells proliferation and induces apoptosis by a caspase-dependent pathway and through a NF-κB-mediated mechanism.
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