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  • Title: Iridium catalyzed asymmetric hydrogenation of cyclic imines of benzodiazepinones and benzodiazepines.
    Author: Gao K, Wu B, Yu CB, Chen QA, Ye ZS, Zhou YG.
    Journal: Org Lett; 2012 Aug 03; 14(15):3890-3. PubMed ID: 22799531.
    Abstract:
    Highly enantioselective Ir-catalyzed hydrogenation of seven-membered cyclic imines of benzodiazepinones and benzodiazepines was achieved with up to 96% ee. This method provides a direct access to synthesize a range of chiral cyclic amines existing in numerous important natural products and clinical drugs.
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