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  • Title: A highly sensitive fluorescent probe for HClO and its application in live cell imaging.
    Author: Zuo QP, Li ZJ, Hu YH, Li B, Huang LH, Wang CJ, Liu SK, Liao HQ.
    Journal: J Fluoresc; 2012 Sep; 22(5):1201-7. PubMed ID: 22802149.
    Abstract:
    A new rhodamine-based probe 1 was designed and synthesized as a new fluorescent molecular probe for HClO in PBS buffer at physiological condition. The free probe 1 almost nonfluorescence, however, a drastic enhancement of fluorescence intensity was observed in the presence of HClO. The new probe 1 exhibits good sensitivity and selectivity for HClO over other reactive oxygen and/or nitrogen species in PBS buffer, and the probe was successfully applied to image endogeneous HClO in the living cells.
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