These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Correlation between the protein/creatinine ratio in spot urine and 24-hour urine protein.
    Author: Montero N, Soler MJ, Pascual MJ, Barrios C, Márquez E, Rodríguez E, Berrada A, Riera M, Coca L, Orfila MA, Pascual J.
    Journal: Nefrologia; 2012 Jul 17; 32(4):494-501. PubMed ID: 22806284.
    Abstract:
    INTRODUCTION: Measurement of the protein content in a 24-hour urine sample is the definitive method of establishing the presence of abnormal proteinuria. However, the urine collection is cumbersome. The spot urine protein to creatinine ratio seems to be a reliable diagnostic tool for urine protein measurement. OBJECTIVE: Our aim was to evaluate the spot urine protein/creatinine ratio against 24-h urine total protein excretion in different proteinuria ranges by comparing samples collected simultaneously in patients of Hospital del Mar during the last year. MATERIAL AND METHOD: Observational, cross-sectional study of 159 consecutive paired determinations of 24-h urine total protein excretion and the spot urine protein/creatinine ratio (P/C) in renal patients. The strength of the correlation was determined by calculating the intraclass correlation coefficient (ICC) and the Spearman correlation coefficient (SCC). RESULTS: Among all groups, there was a significant correlation between 24-hour proteinuria and the P/C ratio (SCC: r=0.91, P<0.001). The correlation in different levels of proteinuria were: <300 mg (SCC: r=0.498, P<0.001; ICC: 0.46), 300-3,499 mg (SCC: r=0.828, P<0.001; ICC: 0.66) and ≥3,500 mg (SCC: r=0.181, P=NS; ICC: 0.18). CONCLUSIONS: In summary, a strong correlation was observed between spot urine protein/creatinine ratio and 24-h urine total protein excretion in proteinuria levels from 300 mg/day to 3,499 mg/day. A lower correlation was also maintained in 24-h urine total protein <300 mg. In our experience, there is no relevant correlation between spot urine protein/creatinine ratio and 24-h urine total protein excretion in nephrotic-range proteinuria.
    [Abstract] [Full Text] [Related] [New Search]