These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Precursor-directed syntheses and biological evaluation of new elansolid derivatives.
    Author: Steinmetz H, Zander W, Shushni MA, Jansen R, Gerth K, Dehn R, Dräger G, Kirschning A, Müller R.
    Journal: Chembiochem; 2012 Aug 13; 13(12):1813-7. PubMed ID: 22807264.
    Abstract:
    The antibiotic elansolid C1 (8) was isolated from Chitinophaga sancti strain FxGBF13 after fermentation in the presence of anthranilic acid. Remarkably, 8 was also obtained by addition of anthranilic acid to a crude fermentation extract containing the macrolide elansolid A2 (1*). This Michael-type conjugate addition allowed us to generate 21 new derivatives of elansolid C1 (9-29) by using various nucleophiles. Biological activities of all derivatives were evaluated against Staphylococcus aureus, Micrococcus luteus, and the mouse cell line L929.
    [Abstract] [Full Text] [Related] [New Search]